Hydroxy B-12 Extreme - 4,000 mcg per serving, 60 tablets

SKU: PH638

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ProHealth’s Hydroxy B-12 Extreme contains hydroxycobalamin, a unique form of vitamin B12 that is naturally produced by bacteria in the digestive tract when food sources are broken down. Compared with some of the more common forms of vitamin B12 found in supplements such as cyanocobalamin and methylcobalamin, hydroxycobalamin provides distinctive benefits to protect against age-related health decline.

Hydroxy B-12 Extreme

  • Enhances cellular health by protecting against DNA damage
  • Promotes energy production by supporting ATP synthesis health
  • Supports healthy brain aging by aiding in the regeneration of myelin
  • Provides mood support by serving as a cofactor in the synthesis of neurotransmitters

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Research-Supported Benefits:

Regulates Cellular Health. Vitamin B12 plays a crucial role in DNA synthesis and repair, and its deficiency has been associated with disruptions in these processes. (1) In part, Vitamin B12 helps support DNA integrity by aiding in the reduction of homocysteine levels in the body. Homocysteine is an amino acid that when elevated, induces several types of DNA damage including DNA strand breaks, which is believed to be a key contributor to accelerated cellular aging. (2)

Enhances Energy Production. A deficiency of vitamin B12 contributes to reduced energy production within the body. Vitamin B12 functions as a cofactor to create SAMe (S-adenosylmethionine) in the body, which is a methyl donor nutrient that helps support mitochondrial function and ATP production.

Promotes Cognitive Health. Maintaining adequate vitamin B12 is essential for supporting healthy brain aging, and low vitamin B12 levels are associated with impaired memory and cognition. (3) Animal research shows that supplementing with vitamin B12 may help protect against age-related brain health decline associated with amyloid beta (Aβ) formation. (4)

Supports Mood. Vitamin B12 is involved in the synthesis of key mood-regulating neurotransmitters serotonin and dopamine. Serotonin, often referred to as the "feel-good" neurotransmitter, is synthesized from the amino acid tryptophan with the help of SAMe, which requires adequate levels of vitamin B12 to function optimally. Dopamine is a neurotransmitter associated with reward, pleasure, and motivation that also relies on vitamin B12 for synthesis. Research shows that vitamin B12 deficiency is associated with mood dysregulation including irritability and personality changes. (5) 


1. Alzoubi KH, Bayraktar E, Khabour O, Al-Azzam SI. Vitamin B12 protects against DNA damage induced by hydrochlorothiazide. Saudi Pharm J. 2018;26(6):786-789. doi:10.1016/j.jsps.2018.04.005

2. Yan Y, Yin Y, Feng X, et al. Homocysteine aggravates DNA damage by impairing the FA/Brca1 Pathway in NE4C murine neural stem cells. Int J Med Sci. 2020;17(16):2477-2486. Published 2020 Sep 9. doi:10.7150/ijms.49246

3. Jatoi S, Hafeez A, Riaz SU, Ali A, Ghauri MI, Zehra M. Low Vitamin B12 Levels: An Underestimated Cause Of Minimal Cognitive Impairment And Dementia. Cureus. 2020;12(2):e6976. Published 2020 Feb 13. doi:10.7759/cureus.6976

4. Lam AB, Kervin K, Tanis JE. Vitamin B12 impacts amyloid beta-induced proteotoxicity by regulating the methionine/S-adenosylmethionine cycle. Cell Rep. 2021;36(13):109753. doi:10.1016/j.celrep.2021.109753

5. Sangle P, Sandhu O, Aftab Z, Anthony AT, Khan S. Vitamin B12 Supplementation: Preventing Onset and Improving Prognosis of Depre**ion. Cureus. 2020;12(10):e11169. Published 2020 Oct 26. doi:10.7759/cureus.11169

  • Hydroxycobalamin is a unique form of vitamin B12 that plays a critical role in supporting methylation, DNA repair, energy production, brain health, mood, and longevity.
  • Vitamin B12 is a cofactor for the enzyme methionine synthase, which participates in the conversion of homocysteine to methionine.
  • Methionine is an essential amino acid that serves as a precursor for S-adenosylmethionine (SAMe), a crucial methyl donor in various cellular reactions.
  • SAMe, derived from methionine with the help of vitamin B12, is involved in methylation reactions.
  • Methylation reactions play a key role in the synthesis of DNA, RNA, proteins, and neurotransmitters, all of which are vital for cellular function and energy metabolism.
  • Methylation reactions, facilitated by SAMe, contribute to the synthesis of ATP, the primary energy currency of cells.
  • SAMe is also involved in the methylation of phospholipids, which are integral components of cell membranes and play a role in cellular signaling and energy production.
  • Vitamin B12 is essential for maintaining the health and function of mitochondria, the cellular organelles responsible for energy production through oxidative phosphorylation.
  • Mitochondria utilize nutrients, including those derived from methionine and its associated methyl donors, to generate ATP.
Supplement Facts
Serving Size: 1 Tablet
Servings Per Container: 60
Amount Per Serving %DV
Vitamin B-12 (as Hydroxycobalamin hydrochloride)
4000 mcg
  • OTHER INGREDIENTS: Sorbitol, natural strawberry flavor, rice extract blend, grape skin, and silicon dioxide.
  • DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, fish, shellfish, tree nuts, peanuts.
  • SUGGESTED DAILY USE: Take 1 tablet daily, allow tablet to fully dissolve under your tongue, then swallow, or as recommended by your healthcare professional.
  • CAUTION: Not intended for use by pregnant or nursing women. Not formulated for use by children. If you have a medical condition or are taking medications consult with your healthcare professional before using this product.
  • NOTE: Store in a cool, dry place. Do not use if tamper evident seal is broken or missing. KEEP OUT OF REACH OF CHILDREN.
  • Longevity-Centric. ProHealth's Hydroxy B12 Extreme was specifically formulated to reduce symptoms of age-related health decline.
  • Unique Form. Compared to other supplement brands using ineffective forms and poorly absorbed forms of vitamin B12, ProHealth’s Hydroxy B12 Extreme contains the Hydroxocobalamin form of vitamin B12, which is distinct health benefits for longevity and cellular health.
  • Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
  • Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.

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Customer Reviews

Based on 2 reviews
Jina B.
Easy to take, tastes great!

Having a high quality b-12 that I can take under my tongue is wonderful! Some b-12 supplements can taste metallic but this has no weird aftertaste and tastes like berries. I can even get my husband to take it everyday, which is a total win. Plus it has a unique source of b-12 that is perfect for long-term health benefits.

Better than methyl b-12!

I thought methyl b-12 was the best until I tried hydroxy b-12. While it is too soon to tell (only been supplementing with hydroxy b-12 for four weeks), the immediate energy boost provided by hydroxy b-12 compared to methyl b-12 has alone won me over!

Frequently asked questions

Vitamin B12 supplements can be taken with or without food, as absorption is generally not significantly affected by food. However, some people may prefer taking it with a meal to reduce the risk of stomach upset.
In certain cases, individuals with specific dietary restrictions, older adults, or those with absorption issues may benefit from B12 supplementation even if they are not deficient. However, it's essential to consult with a healthcare provider for personalized guidance.
There is no specific time of day that is considered optimal for taking vitamin B12. It can be taken in the morning or evening based on personal preference. Some people prefer taking it in the morning to avoid potential interference with sleep.
Vitamin B12 is water-soluble, and excess amounts are usually excreted in urine. However, it's advisable not to exceed recommended dosages, as excessively high levels may have adverse effects.
Vitamin B12 deficiency has been associated with fatigue, and supplementation may be beneficial for individuals with a deficiency. However, fatigue can have various causes, and it's essential to address underlying issues with the guidance of a healthcare professional.