TMG Pro Powder - 100 grams

SKU: PH554

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Regular price $12.33
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A Methyl Donor That Complements NMN Supplementation

  • Supports cardiovascular health*
  • Promotes healthy homocysteine levels*
  • Helps replenish the body's methyl pool*

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Supplement Facts
Serving Size: 1 Level Scoop 
Servings Per Container: 100
Amount Per Serving %DV
Trimethylglycine (TMG) (Betaine Anhydrous)  1,000 mg
† Daily Value not established

  • Contains No: Milk, egg, soy, gluten, wheat, fish, shellfish or tree nut ingredients.
  • Suggested Daily Use: Take 1-3 scoops daily, preferably with food, or as directed by your healthcare practitioner.
  • Note: This product is very sensitive to moisture/humidity which may affect product stability. Store in a cool dry place.
  • Caution: Consult a physician if you are pregnant and/or nursing, taking medication, or have a medical condition.

Trimethylglycine (TMG), also known as betaine anhydrous, is an amino acid that supports the body's methylation processes. Methylation is a fundamental biochemical process in which one carbon atom and three hydrogen atoms (CH3) are transferred from one molecule to another. This process is responsible for numerous important bodily functions, such as:

  • Cell division
  • Cellular energy production
  • Clearing histamine
  • Metabolism
  • DNA expression (epigenetics)
  • Forming neurotransmitters
  • Producing free radical scavenging antioxidants

Our bodies contain a “methyl pool” of CH3 that is available whenever needed. As long as we have enough methyl groups stored in the pool, methylation typically is not a problem. However, there are a couple of things that may contribute to the depletion of the body's methyl pool.

  1. MTHFR Variants - Methylenetetrahydrofolate reductase (MTHFR) is a gene with common mutations that can interfere with the methylation process, causing high levels of homocysteine (a known risk factor in heart disease) in the blood and low folate levels. Up to 40% of the population may have one or both genetic mutations.
  2. Aging and Epigenetics - Methylation of DNA plays a crucial role in epigenetics, switching different sequences of your genetic material on and off as needed. The body's methylation ability and subsequent DNA expression is known to decline with age. Anti-aging researchers think these changes in DNA expression may be a contributing factor to many age-related diseases.*

NMN Supplementation and Methylation Support

When taken as a supplement, NMN may require the use of methyl groups to help facilitate the conversion of NAD+ in your cells, thereby activating sirtuin genes and promoting longevity. Although there is currently no evidence suggesting NMN’s natural methylation process depletes the methyl pool, many top anti-aging experts suggest that safeguarding against methyl depletion may be a wise proactive step to augment your NMN intake. TMG, the choice of many of those experts, is an excellent way to help support your body's ability to maintain an adequate methyl pool.

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Customer Reviews

Based on 52 reviews
Mladen V.

TMG Pro Powder - 100 grams

TMG pro

I take with [N][M][N]. It does give more energy and no side affects.

Works as advertised, but love the company

I mainly got this to supply butyls and such when taking [N] [M] [N].
On another note, their nutritional advisor, joe, is very knowledgeable about these things. He was instrumental in helping me select the right products based on my concerns and goals. I wanted small trial packs of [N] [M] [N] and Resveratrol, prohealth has a good deal on all 3, with the tmg, to try them out. I’ll up my doses a little, after talking to joe, and another reputable brand did have a similar bag a little cheaper, but I asked if they’d price match it and they did! I still used a coupon also. I got my refund, for the price match difference the next day. I got my shipment in record time, I was surprised. I got the free shipping. The [N] [M] [N] is working for me, and prohealth customer service and advisor s are top notch. I’m definitely coming here for my next order. I’m usually not one to rave, but they really do deserve it.

Juan C.S.
So far so good

I just started this product with the family. I did read a lot about it before ordering it. I have not seen major changes yet but so far so good

Paul C.

TMG Pro Powder (100 grams) (Bulk Powder) by ProHealth Longevity

Barry H.
Bulk [N] [M] [N]

I feel I am having positive results. I have more energy.

Linda R.

Easy to take and pleasant taste

Ross H.
Great Addition to Taking [N] [M] [N]

Great support to help for possible reduction of methyl groups when taking [N] [M] [N].


Adding this to my routine has generated early morning energy

good taste but the scooper is terrible

I like the flavor of this powder. Doesn't torture me to take the TMG. I try to avoid additives and other unnecessary ingredients since I take a lot of supplements. ProHealth is high quality .. The scoop is flat on top and the powder goes all over my face.. I would prefer a scooper handle to be rounded and not hold powder on it as i'm scooping it out of the bag. Would also love the powder to be in an additional plastic bag inside so I can store my scooper inside without leaving it in the powder mix. Currently I'm taping it to the outside of the bag but the tape desn't stick well.

Frequently asked questions

It’s suggested to take 1 - 3 scoops daily, preferably with food, or as directed by a healthcare practitioner.
This product is very sensitive to moisture/humidity which may affect product stability. Store in a cool dry place. Keep out of reach of children.
TMG is generally considered safe, but some people may experience digestive issues like cramping, bloating, nausea, or diarrhea.