ProHealth Longevity

TMG Pro Powder (250 grams) (Bulk Powder) by ProHealth Longevity

SKU: PH555


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A Methyl Donor That Complements NMN Supplementation

  • Supports cardiovascular health*
  • Promotes healthy homocysteine levels*
  • Helps replenish the body's methyl pool*

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Supplement Facts
Supplement Facts
Serving Size: 1 Level Scoop
Servings Per Container: 250
Amount Per Serving %DV
Trimethylglycine (TMG) (Betaine Anhydrous) 1,000 mg
† Daily Value not established
REV. 01.22
  • Does Not Contain: Milk, egg, soy, gluten, wheat, fish, shellfish or tree nut ingredients.
  • Suggested Daily Use: Take 1 - 3 scoops daily, preferably with food, or as directed by a healthcare practitioner.
  • Note: This product is very sensitive to moisture/humidity which may affect product stability. Store in a cool dry place. 
  • Caution: Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Trimethylglycine (TMG), also known as betaine anhydrous, is an amino acid that supports the body's methylation processes. Methylation is a fundamental biochemical process in which one carbon atom and three hydrogen atoms (CH3) are transferred from one molecule to another. This process is responsible for numerous important bodily functions, such as:

  • Cell division
  • Cellular energy production
  • Clearing histamine
  • Metabolism
  • DNA expression (epigenetics)
  • Forming neurotransmitters
  • Producing free radical scavenging antioxidants

Our bodies contain a “methyl pool” of CH3 that is available whenever needed. As long as we have enough methyl groups stored in the pool, methylation typically is not a problem. However, there are a couple of things that may contribute to the depletion of the body's methyl pool.

  1. MTHFR Variants - Methylenetetrahydrofolate reductase (MTHFR) is a gene with common mutations that can interfere with the methylation process, causing high levels of homocysteine (a known risk factor in heart disease) in the blood and low folate levels. Up to 40% of the population may have one or both genetic mutations.

  2. Aging and Epigenetics - Methylation of DNA plays a crucial role in epigenetics, switching different sequences of your genetic material on and off as needed. The body's methylation ability and subsequent DNA expression is known to decline with age. Anti-aging researchers think these changes in DNA expression may be a contributing factor to many age-related diseases.*

NMN Supplementation and Methylation Support

When taken as a supplement, NMN may require the use of methyl groups to help facilitate the conversion of NAD+ in your cells, thereby activating sirtuin genes and promoting longevity. Although there is currently no evidence suggesting NMN’s natural methylation process depletes the methyl pool, many top anti-aging experts suggest that safeguarding against methyl depletion may be a wise proactive step to augment your NMN intake. TMG, the choice of many of those experts, is an excellent way to help support your body's ability to maintain an adequate methyl pool.

Customer Reviews

Based on 31 reviews
Alex C.
Good product

It was easy to add the liquids and very affordable.

Sean W.
Tmg pro powder

I follow dr david Sinclair's protocol. The tmg from pro health is a great product and great quality.

Brian H.
Great Product

Met our expectations

Rajender P.

TMG Pro Powder (500 grams) (Bulk Powder) by ProHealth Longevity


Great product

David H.
Good compliment to NMN

I take NMN every morning and then later in the morning add this to boost the impact…. I recommend this based on what I have read...

It smells a little fishy but once mixed with anything that goes away given the small serving size...

Thomas H.
Decent Product bad smell

Smells like bad fish

Carrie S.

Incorporating into my daily routine!

Teresa B.
TMG Powder

NMN companion. Taste good. Time will tell.

Mark B.

TMG is easy to take and works well wirh NMN.