Ergothioneine - 25 mg, 30 capsules

SKU: PH646

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Ergothioneine is a powerful amino acid that helps fight the signs of aging and supports numerous aspects of health.

  • Supports longevity by aiding in telomere length maintenence 1
  • Combats oxidative stress in the brain to support cognition 2
  • Protects the heart and is associated with reduced cardiovascular mortality 3

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Research-Supported Benefits:

Supports Longevity. Research shows that ergothioneine supports longevity by protecting against accelerated telomere shortening. (1) Longer telomeres are a powerful predictor of increased lifespan and healthspan. (4)

Maintains Cellular Health. Ergothioneine has been shown to reduce levels of oxidative stress. High levels of oxidative stress may contribute to DNA damage, a decline in ATP (cellular energy) production and elevated inflammatory markers. (5)

Promotes Heart Health. By reducing oxidative stress, ergothioneine exhibits powerful cardioprotective properties. Oxidative stress is associated with accelerated aging of heart cells, studies show ergothioneine reduces cardiac-related mortality risk. (6)

Enhances Brain Health. Low levels of ergothioneine are correlated with neurodegeneration and cognitive impairment. (7) Animal studies have found that administration of ergothioneine improves markers of memory and mood. (8)

Improves Performance. Research suggests ergothioneine may improve markers associated with fitness and muscle health. One study found that administration ergothioneine to mice increased time to exhaustion during aerobic activity and enhanced protein synthesis post-exercise. (9)


1. Samuel P, Tsapekos M, de Pedro N, Liu AG, Casey Lippmeier J, Chen S. Ergothioneine Mitigates Telomere Shortening under Oxidative Stress Conditions. J Diet Suppl. 2022;19(2):212-225. doi:10.1080/19390211.2020.1854919

2. Wijesinghe P, Whitmore CA, Campbell M, et al. Ergothioneine, a dietary antioxidant improves amyloid beta clearance in the neuroretina of a mouse model of Alzheimer's disease. Front Neurosci. 2023;17:1107436. Published 2023 Mar 14. doi:10.3389/fnins.2023.1107436

3. Dare A, Elrashedy AA, Channa ML, Nadar A. Cardioprotective Effects and in-silico Antioxidant Mechanism of L-Ergothioneine in Experimental Type-2 Diabetic Rats. Cardiovasc Hematol Agents Med Chem. 2022;20(2):133-147. doi:10.2174/1871525719666210809122541

4. Heidinger BJ, Blount JD, Boner W, Griffiths K, Metcalfe NB, Monaghan P. Telomere length in early life predicts lifespan. Proc Natl Acad Sci U S A. 2012;109(5):1743-1748. doi:10.1073/pnas.1113306109

5. Fu TT, Shen L. Ergothioneine as a Natural Antioxidant Against Oxidative Stress-Related Diseases. Front Pharmacol. 2022;13:850813. Published 2022 Mar 18. doi:10.3389/fphar.2022.850813

6. Smith E, Ottosson F, Hellstrand S, et al. Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease. Heart. 2020;106(9):691-697. doi:10.1136/heartjnl-2019-315485

7. Wu LY, Kan CN, Cheah IK, et al. Low Plasma Ergothioneine Predicts Cognitive and Functional Decline in an Elderly Cohort Attending Memory Clinics. Antioxidants (Basel). 2022;11(9):1717. Published 2022 Aug 30. doi:10.3390/antiox11091717

8. Ishimoto T, Kato Y. Ergothioneine in the brain. FEBS Lett. 2022;596(10):1290-1298. doi:10.1002/1873-3468.14271

9. Fovet T, Guilhot C, Delobel P, Chopard A, Py G, Brioche T. Ergothioneine Improves Aerobic Performance Without Any Negative Effect on Early Muscle Recovery Signaling in Response to Acute Exercise. Front Physiol. 2022;13:834597. Published 2022 Feb 9. doi:10.3389/fphys.2022.834597

  • Ergothioneine is an amino acid that your body is unable to make on its own but can be obtained from eating foods such as certain types of mushrooms and organ meat.
  • As you age, levels of ergothioneine decline in the body, potentially contributing to a decline in cellular, brain, heart, and muscle health.
  • Ergothioneine is absorbed in the small intestine and transported throughout the body via a specific transporter known as the Organic Cation Transporter 1 (OCTN1). This transporter is highly selective for ergothioneine, allowing it to enter cells efficiently.
  • Once inside the cells, ergothioneine primarily exerts its effects as a potent antioxidant. It works by donating electrons to neutralize harmful free radicals and reactive oxygen species (ROS) that are generated during normal cellular metabolism and in response to environmental stressors.
  • Administration of ergothioneine in animal studies has been shown to reduce oxidative stress, mediate inflammatory markers, and promote cellular, brain, and heart health.
Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 30
Amount Per Serving %DV
L-Ergothioneine 25 mg
† Daily Value not established
REV. 10.23

  • OTHER INGREDIENTS: Vegetable capsule, rice flour.
  • DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, fish, shellfish, tree nuts, peanuts.
  • SUGGESTED DAILY USE: Take 1 capsule per day, or as directed by your healthcare professional.
  • NOTE: Store in a cool, dry place. Do not use if tamper evident seal is broken or missing.
  • CAUTION: Not intended for use by pregnant or nursing women. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product. KEEP OUT OF REACH OF CHILDREN.
  • Unique Formulation. Compared to the majority of products on the market with lower doses, ProHealth's Ergothioneine contains a clinically effective dose of 25 mg of ergothioneine per serving.
  • Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
  • Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.

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Customer Reviews

Based on 7 reviews
Danni N.

Ergothioneine - 25 mg, 30 capsules

Mary A.
ProHealth Longetivity

Well packaged products.

Amazing product!

I'm primarily interested in L-Ergothioneine for its possible neuroprotective effects as well as eye health. and its protection against oxidative damage specific to the heart and brain. I already have more energy and sharper mind.....but its benefits are supposed to be long term.
I highly recommend this company and its product!

John G.
A unique antioxidant … a vitamin ?

Good evidence for ergothionine’s unique role in cardiovascular and brain health..
It’s depletion has serious consequences , hence many consider it ‘a vitamin’

Sri M.
Ergothioneine not for thee

I love and trust prohealth products, but this gave me a sinking feeling in my heart. I'm very sensitive and carefully think about how I feel when I've tried 200+ supplements not from Prohealth. Their NMN seemas perfect.

James S.

Higher dose than other brands.

Joe C.
Ergothioneine As an ergogenic

Excited to add this underrated supplement to my longevity stack!

Frequently asked questions

There is no specific time of day that is considered ideal for taking ergothioneine. You can take it at a time that best fits your daily routine. Some individuals prefer to take it with breakfast or lunch to ensure they remember to include it with their meals.
While ergothioneine is naturally found in foods like mushrooms and some grains, it may be challenging to obtain sufficient amounts solely through diet. Factors like dietary preferences, availability of ergothioneine-rich foods, and individual nutritional needs can affect your intake. Supplements offer a convenient way to ensure you meet your ergothioneine requirements, especially if you have specific health goals or concerns.