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Brain Health
Cellular Health
Healthy Aging
Free Nutritional Advisor
Free Nutritional AdvisorSupport and Maintain Healthy Brain Function
- Supports longevity
- Promotes brain health
- Enhances cellular health
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Research-Supported Benefits:
Supports Longevity. Fisetin supports longevity by aiding in the removal of senescent cells from the body. (1) Senescent cells, also known as zombie cells, accumulate as we age and contribute to oxidative stress, inflammation and accelerated cellular aging. Research shows that removing senescent cells extends lifespan in animals. (1)
Promotes Brain Health. Research shows that fisetin supplementation may reduce symptoms of age-related brain health decline. (2) Functioning as an antioxidant to reduce neuroinflammation, fisetin has been shown to enhance learning and memory. (2) Additionally, fisetin may prevent brain cell death associated with brain aging. (2)
Enhances Cellular Health. Oxidative stress contributes to cellular damage and accelerated cellular aging. While inflammation and oxidative stress are natural, high levels of oxidative stress and inflammation dramatically reduce longevity. Research shows that fisetin supplementation may reduce oxidative stress and inflammation due to its antioxidant effects, thus promoting longevity. (3)
References:
1. Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018;36:18-28. doi:10.1016/j.ebiom.2018.09.015
2. Nabavi SF, Braidy N, Habtemariam S, Sureda A, Manayi A, Nabavi SM. Neuroprotective Effects of Fisetin in Alzheimer's and Parkinson's Diseases: From Chemistry to Medicine. Curr Top Med Chem. 2016;16(17):1910-1915. doi:10.2174/1568026616666160204121725
3. Jiang K, Yang J, Xue G, Dai A, Wu H. Fisetin Ameliorates the Inflammation and Oxidative Stress in Lipopolysaccharide-Induced Endometritis. J Inflamm Res. 2021;14:2963-2978. Published 2021 Jul 5. doi:10.2147/JIR.S314130
| Supplement Facts | ||
|---|---|---|
| Serving Size: 1 Capsule | ||
| Servings Per Container: 60 | ||
| Amount Per Serving | %DV | |
|
Proprietary Lifespan Absorption Blend™ Glucomannan (from Konjac Root), Marshmallow Root Powder, Green Tea Leaf Extract (45% EGCG), Long Pepper Fruit Extract (20:1), Quercetin (from Sophora japonica Flower Extract), Turmeric Root Extract (95% Curcuminoids)s |
350 mg | † |
| Fisetin (from Rhus succedanea Stem Extract) |
125 mg | † |
| Medium-Chain Triglycerides (MCT) Oil Powder (from Coconut) |
25 mg | † |
| † Daily Value (DV) not established | ||
- OTHER INGREDIENTS: Vegetable cellulose (capsule), brown rice flour.
- SUGGESTED DAILY USE: Take on (1) or two (2) capsules per day.
- CAUTION: For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. KEEP OUT OF REACH OF CHILDREN. Store in a cool and dry place after opening.
- Fisetin is one of the most potent senolytic compounds in existence. Senolytics are defined as nutrients that aid in the removal of senescent cells from the body. As senescent cells accumulate, oxidative stress and longevity decrease.
- DNA damage accelerates cellular aging. Fisetin may protect against DNA damage and promote DNA repair.
- Fisetin exhibits powerful antioxidant effects, reducing oxidative stress and inflammation.
- As we age, our brain cells degrade due to oxidative stress—the buildup of inflammatory compounds called reactive oxygen species. As an antioxidant, fisetin fights off oxidative stress that damages our cells, including neurons. Fisetin also has exhibited beneficial effects on age-related changes in the brain by triggering signaling pathways that promote brain cell growth and neuronal integrity.
- Unique Formulation. The majority of fisetin products have poor absorption. To help, we added a Proprietary Lifespan Absorption Blend™ to dramatically enhance bioavailability and efficacy and support various aspects of health.
- Increased Absorption. To further enhance absorption, we included MCT Oil Powder. Adding a fat to the product helps increases the body’s ability to utilize fisetin.
- Supported for Daily Use. Compared to other fisetin products that are intended to be used 1-2 times per week, our formula is safe enough to be used daily.
- Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
- Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.
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Better Absorption
"I used a different brand of Fisetin for senolytic therapy that did not give me the results I was expecting. I tried the ProHealth Longevity brand and got much better results. I believe this was because it was more bioavailable (better absorption)."
- John R., Verified ProHealth Longevity Customer