TMG Pro Powder - 100 grams

SKU: PH554

Sale price

Regular price $12.33
( / )
  • Have questions about this product?
    Ask one of our experts.
  • click here

Free Nutritional Advisor

Free Nutritional Advisor

A Methyl Donor That Complements NMN Supplementation

  • Supports cardiovascular health*
  • Promotes healthy homocysteine levels*
  • Helps replenish the body's methyl pool*

View Certificate of Analysis »

Supplement Facts
Serving Size: 1 Level Scoop 
Servings Per Container: 100
Amount Per Serving %DV
Trimethylglycine (TMG) (Betaine Anhydrous)  1,000 mg
† Daily Value not established

  • Contains No: Milk, egg, soy, gluten, wheat, fish, shellfish or tree nut ingredients.
  • Suggested Daily Use: Take 1-3 scoops daily, preferably with food, or as directed by your healthcare practitioner.
  • Note: This product is very sensitive to moisture/humidity which may affect product stability. Store in a cool dry place.
  • Caution: Consult a physician if you are pregnant and/or nursing, taking medication, or have a medical condition.

Trimethylglycine (TMG), also known as betaine anhydrous, is an amino acid that supports the body's methylation processes. Methylation is a fundamental biochemical process in which one carbon atom and three hydrogen atoms (CH3) are transferred from one molecule to another. This process is responsible for numerous important bodily functions, such as:

  • Cell division
  • Cellular energy production
  • Clearing histamine
  • Metabolism
  • DNA expression (epigenetics)
  • Forming neurotransmitters
  • Producing free radical scavenging antioxidants

Our bodies contain a “methyl pool” of CH3 that is available whenever needed. As long as we have enough methyl groups stored in the pool, methylation typically is not a problem. However, there are a couple of things that may contribute to the depletion of the body's methyl pool.

  1. MTHFR Variants - Methylenetetrahydrofolate reductase (MTHFR) is a gene with common mutations that can interfere with the methylation process, causing high levels of homocysteine (a known risk factor in heart disease) in the blood and low folate levels. Up to 40% of the population may have one or both genetic mutations.
  2. Aging and Epigenetics - Methylation of DNA plays a crucial role in epigenetics, switching different sequences of your genetic material on and off as needed. The body's methylation ability and subsequent DNA expression is known to decline with age. Anti-aging researchers think these changes in DNA expression may be a contributing factor to many age-related diseases.*

NMN Supplementation and Methylation Support

When taken as a supplement, NMN may require the use of methyl groups to help facilitate the conversion of NAD+ in your cells, thereby activating sirtuin genes and promoting longevity. Although there is currently no evidence suggesting NMN’s natural methylation process depletes the methyl pool, many top anti-aging experts suggest that safeguarding against methyl depletion may be a wise proactive step to augment your NMN intake. TMG, the choice of many of those experts, is an excellent way to help support your body's ability to maintain an adequate methyl pool.

which supplements are right for you?

Our Longevity Health Pros are just a text away with supplement & dietary answers, guidance & support.

Benefits +
How it Works +
How Ours is Better +
Label Information +

Customer Reviews

Based on 64 reviews
Teresa B.
TMG Pro Powder

Take with [N][M][N]

Andrea M.
TMG quality is great!!!

This TMG is such a good quality supplement. I've tried others...but felt an immediate difference I'm health with this one. Will re order. I love it!!!

Fred R.
quality products

If your taking [N][M][N] then you should probably be taking a quality TMG product also since [N][M][N] uses methyl groups at a rapid rate and methyl groups are a valuable commodity used throughout your body, most notably in the repair chromosome double strand breaks which is of vital importance. I trust ProHealth to provide a quality TMG product as with most of their other products.


Very good product!

Curt T.

Seems to wokrk

Christopher P.

TMG Pro Powder - 250 grams

Christopher P.

TMG Pro Powder - 250 grams

Deb B.
Fast shipping, good customer service

I’ve just started the supplements so I can’t speak to efficacy but there haven’t been any side effects and they seem to be high quality. Products arrived quickly and I worked with a rep to get some recommendations.

Garry B.

Great product.


I use this in conjunction with multi other products in a full support regiment .
seems to be just fine .

Frequently asked questions

It’s suggested to take 1 - 3 scoops daily, preferably with food, or as directed by a healthcare practitioner.
This product is very sensitive to moisture/humidity which may affect product stability. Store in a cool dry place. Keep out of reach of children.
TMG is generally considered safe, but some people may experience digestive issues like cramping, bloating, nausea, or diarrhea.