TMG Pro Tablets - 1000 mg, 120 tablets

SKU: PH568

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95% would recommend this product (20 votes)

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A methyl donor that supports heart health and liver detoxification.

  • Supports cardiovascular health*
  • Promotes healthy homocysteine levels*
  • Helps replenish the body's methyl pool*

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Supplement Facts
Serving Size: 1 Tablet
Servings Per Container: 120
Amount Per Serving %DV
Trimethylglycine (TMG) (Betaine Anhydrous) 1 g (1,000 mg)
† Daily Value not established
REV. 05.22
  • Other Ingredients: Cellulose, Stearic Acid (vegetable source), Croscarmellose Sodium, Magnesium Stearate (vegetable source) and Vegetarian Coating.
  • Not Manufactured With: Milk, egg, soy, gluten, wheat, fish, shellfish or tree nut ingredients.
  • Suggested Daily Use: Take 1-6 tablets daily, divided into 2 doses, or as recommended by your healthcare provider. 
  • Note: Keep the bottle tightly closed at all times in between usage. Keep the freshness packet in bottle. This product is very sensitive to moisture/humidity which may affect product stability. Store in a cool dry place after opening.
  • Caution: Consult physician if pregnant/nursing, taking medication, or have a medical condition. KEEP OUT OF REACH OF CHILDREN.

Trimethylglycine (TMG), also known as betaine anhydrous, is an amino acid that supports the body's methylation processes. Methylation is a fundamental biochemical process in which one carbon atom and three hydrogen atoms (CH3) are transferred from one molecule to another. This process is responsible for numerous important bodily functions, such as:

  • Cell division
  • Cellular energy production
  • Clearing histamine
  • Metabolism
  • DNA expression (epigenetics)
  • Forming neurotransmitters
  • Producing free radical scavenging antioxidants

Our bodies contain a “methyl pool” of CH3 that is available whenever needed. As long as we have enough methyl groups stored in the pool, methylation typically is not a problem. However, there are a couple of things that may contribute to the depletion of the body's methyl pool.

  1. MTHFR Variants - Methylenetetrahydrofolate reductase (MTHFR) is a gene with common mutations that can interfere with the methylation process, causing high levels of homocysteine (a known risk factor in heart disease) in the blood and low folate levels. Up to 40% of the population may have one or both genetic mutations.
  2. Aging and Epigenetics - Methylation of DNA plays a crucial role in epigenetics, switching different sequences of genetic material on and off as needed. The body's methylation ability and subsequent DNA expression is known to decline with age. Anti-aging researchers think these changes in DNA expression may be a contributing factor to many age-related diseases.*

NMN Supplementation and Methylation Support

When taken as a supplement, NMN may require the use of methyl groups to help facilitate the conversion of NAD+ in cells, thereby activating sirtuin genes and promoting longevity. Although there is currently no evidence suggesting NMN’s natural methylation process depletes the methyl pool, many top anti-aging experts suggest that safeguarding against methyl depletion may be a wise proactive step to augment NMN intake. TMG, the choice of many of those experts, is an excellent way to help support the body's ability to maintain an adequate methyl pool.

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Customer Reviews

Based on 47 reviews
James D.
Big Pill To Swallow

Have to cut in half

Krista K.
Pro Health Supplements

TMG I did not know initially know about TMG and helping with methylation when taking [N][M][N] ProHealth supplements are incredible. I highly recommend them to everyone. I love that they are an American company and that you can get all the certs and info about them and their research on the site. Fantastic products and company

Michael L.
Too early to tell

My Pro Health products were delivered in a timely manner. The company has treated me well. I would give 5 stars but I haven't really noticed any changes yet. That being said I ordered my [N][M][N] from another company and maybe the lack of results is more about the [N][M][N] than it is the TMG. I am looking at trying [N][M][N] from another company as soon as my current supply runs out. I am not experiencing any side affects and take a pill a day in the morning on an empty stomach and sometimes second one after dinner.

Sue L.
TMG PRO 1000

Relative to another brand of TMG which I purchased previously, this product is excellent. No side effects whatsoever. Very satisfied.

Kevin P.

I am happy with the quality of the product.

Christopher F.
Excellent product

I have had excellent results with all of the pro health products I’ve used.

Cindy L.
TMG Pro.

It’s good products. Give me a lot of energy.

Asi M.

TMG Pro Tablets (1000 mg, 120 tablets) by ProHealth Longevity

Jennifer M.
Great supplement

I am very happy with the quality of this supplement and will continue to order.

Zofia N.

I am taking TMG following David Sinclair advice.

Frequently asked questions

It’s suggested to take 1-6 tablets daily divided into 2 doses, or as directed by a healthcare practitioner.
Keep the bottle tightly closed at all times in between usage. Keep the fresh packet in the bottle. This product is very sensitive to moisture/humidity which may affect product stability. Keep out of reach of children.
TMG is generally considered safe, but some people may experience digestive issues like cramping, bloating, nausea or diarrhea.