10% Off $75 Orders! Use Code SAVE10P Shop Now
One use per customer. Not available with Autoship. Expires 5/28/18.

A Highly Expressed Human Protein, Apolipoprotein B-100, Serves as an Autoantigen in a Subgroup of Patients with Lyme Disease

1 Star2 Stars3 Stars4 Stars5 Stars (No Ratings Yet)
Loading...

By J. T. Crowley et al.
 
Abstract
 
To discover novel autoantigens associated with Lyme arthritis (LA), we identified T cell epitopes presented in vivo by HLA-DR molecules in patients’ inflamed synovial tissue or joint fluid and tested each epitope for autoreactivity.
 
Using this approach, we identified the highly expressed human protein, apolipoprotein B-100 (apoB-100), as a target of T and B cell responses in a subgroup of LA patients. Additionally, the joint fluid of these patients had markedly elevated levels of apoB-100 protein, which may contribute to its autoantigenicity.
 
In patients with antibiotic-refractory LA, the magnitude of apoB-100 antibody responses correlated with increased numbers of plasma cells in synovial tissue, greater numbers and activation of endothelial cells, and more synovial fibroblast proliferation.
 
Thus, a subset of LA patients have high levels of apoB-100 in their joints and autoreactive T and B cell responses to the protein, which likely contributes to pathogenic autoimmunity in patients with antibiotic-refractory LA.
 
Source: Crowley JT, Drouin EE, Pianta A, Strle K, Wang Q, Costello CE, Steere AC. A Highly Expressed Human Protein, Apolipoprotein B-100, Serves as an Autoantigen in a Subgroup of Patients with Lyme Disease. Journal of Infectious Diseases, online first, 2015 May 26.

1 Star2 Stars3 Stars4 Stars5 Stars (No Ratings Yet)
Loading...



Leave a Reply