Absence of Borrelia burgdorferi-specific immune complexes in Chronic Fatigue Syndrome (CFS)

Chronic fatigue syndrome (CFS) and Lyme disease often share

clinical features, especially fatigue, contributing to concern

that Borrelia burgdorferi (Bb), the cause of Lyme disease, may

underlie CFS symptoms. We examined 39 CFS patients and 40

healthy controls with a Bb immune complex test. Patients and

controls were nonreactive. Centers for Disease Control and

Prevention-defined CFS patients lacking antecedent signs of

Lyme disease–erythema migrans, Bell’s palsy, or large joint

arthritis–are not likely to have laboratory evidence of Bb


Schutzer SE, Natelson BH

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