Clin Sci (Lond) 2003 Feb 18; [epub ahead of print]
McCully KK, Smith S, Rajaei S, Leigh Jr JS, Natelson BH.
The purpose of this study was to determine if chronic fatigue syndrome (CFS) is associated with reduced blood flow and oxidative delivery to skeletal muscle. Patients with CFS according to CDC criteria (n=19) were compared to normal sedentary subjects (n = 11). Muscle blood flow was measured with Doppler ultrasound after cuff ischemia and after exercise. Muscle oxygen delivery was measured as the rate of post-exercise and post-ischemic oxygen-heme resaturation. Oxygen-heme resaturation was measured in the medial gastrocnemius muscle using continuous wavelength near-infrared spectroscopy. Muscle metabolism was measured using 31P magnetic resonance spectroscopy. CFS and controls were not different in the peak blood flow after cuff ischemia, the rate of recovery of phosphocreatine after submaximal exercise, and the rate of recovery of oxygen saturation after cuff ischemia. In conclusion, CFS patients showed no deficit in blood flow or oxidative metabolism. This suggests that CFS symptoms do not require abnormal peripheral function.
PMID: 12589704 [PubMed – as supplied by publisher]