Journal: Arthritis Res Ther. 2007 Jan 17;8(6):224 [E-publication ahead of print] Authors and affiliation: Williams DA, Gracely RH. Chronic Pain and Fatigue Research Center, Department of Internal Medicine, Division of Rheumatology, University of Michigan Health System, University of Michigan, Ann Arbor, Michigan, USA. [E-mail: firstname.lastname@example.org ] PMID: 17254318 Techniques in neuroimaging such as functional magnetic resonance imaging (fMRI) have helped to provide insights into the role of supraspinal [above the spine] mechanisms in pain perception. This review focuses on studies that have applied fMRI in an attempt to gain a better understanding of the mechanisms involved in the processing of pain associated with Fibromyalgia. This article provides an overview of the nociceptive system [for signaling pain from tissue damage/stress/inflammation] as it functions normally, reviews functional brain imaging methods, and integrates the existing literature utilizing fMRI to study central pain mechanisms in Fibromyalgia.