Chronic Fatigue Syndrome (CFS) differs from fibromyalgia (FM). No evidence for elevated substance P levels in cerebrospinal fluid of patients with CFS

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Levels of substance P were determined in the cerebrospinal
fluid (CSF) in 15 patients with chronic fatigue syndrome
(CFS). All values were within normal range. This is in
contrast to fibromyalgia (FM). The majority of patients with
FM have increased substance P values in the CSF. The results
support the notion that FM and CFS are different disorders in
spite of overlapping symptomatology.

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