50 patients with chronic fatigue syndrome (CFS) and 73
controls were patch tested with 8 metal allergens. We found an
overrepresentation of allergies among the CFS patients, which
was not significant.
However, allergy to nickel occurred in
36% of patients in the CFS group and in 19% of subjects in the
control group (p<0.05). The high frequency of nickel allergy
was more noteworthy in females in the CFS group than among
female controls (52% and 24%, respectively, p<0.05). Similarly, in the males the figures were 14% and 9%. We
suggest that in vivo immunoactivation by ions of nickel, or
metal cross-reacting with nickel, could be an etiological
factor in CFS.
Marcusson JA, Lindh G, Evengard B