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Dermal IgG deposits & increase of mast cells in patients with fibromyalgia (FM)–relevant findings or epiphenomena?

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Skin biopsies from 25 patients with fibromyalgia, 5 healthy
controls, 8 patients with rheumatoid arthritis, and 9 patients
with local chronic pain after whiplash injury, were examined
for the occurrence of IgG deposits and collagen types, using
direct and indirect immunofluorescence, and for dermal
connective tissue mast cells, using semithin Epon sections.

Fibromyalgia skin biopsies had significantly higher values of
IgG deposits in the dermis and vessel walls and showed a
higher reactivity for collagen III. They also had a higher
mean number of mast cells. There was a correlation between the
percentage of damaged/degranulated mast cells and the
individual IgG immunofluorescence scores. These findings
support the hypothesis of neurogenic inflammation involvement
in fibromyalgia.

1 Star2 Stars3 Stars4 Stars5 Stars (23 votes, average: 2.85 out of 5)
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