Does B12 deficiency lead to lack of treatment response to conventional antidepressants? – Source: Psychiatry, Nov 2010

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We present two cases of treatment-resistant depression that improved with recognition and correction of the underlying medical etiology of vitamin B-12 deficiency.

Supplementations of vitamin B-12 to the same antidepressant regimen that the patient had not responded earlier led to response.

Two male subjects who were vegetarians presented with long-standing histories of depression and had not responded to three adequate trials of antidepressants. Upon investigation, the authors found that the subjects had low vitamin B-12 levels. Both cases improved with supplementation of vitamin B-12.

Subjects with depression who do not respond to conventional antidepressants should be evaluated for nutritional factors.

Source: Psychiatry, Nov 2010;7(11):42-44. PMID: 21191533, by Kate N, Grover S, Agarwal M. Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India. [Email:]

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