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Effect of an antibiotic combination on the propagation of Borrelia burgdorferi, causative agent of Lyme disease.

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The effects of combined antibiotics (pefloxacin-doxycycline and pefloxacin-ceftriaxone) were tested on the most prevalent European
Lyme spirochete species, Borrelia garinii by checkerboard dilution. The influence was judged both microscopically and by the measurement of the pH of the culture medium on the 5th day after inoculation. Borreliae propagated quite well at the concentration of 4 mg/l pefloxacin but the motility and the metabolism of the spirochete injured. Neither synergetic nor additive effect of the combination could be registered. Surprisingly, the pefloxacin at a concentration less than 4 mg/l activated both the propagation and the metabolism of borreliae, showing a clear antagonistic effect with doxycycline and ceftriaxone. Unless well-controlled animal model will prove the contrary, quinolones neither alone nor in combination should be used in
Lyme borreliosis.

Orv Hetil. 1999 Jul 4;140(27):1529-32. English Abstract

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