Effects of Vitamin D Therapy on Quality of Life in Patients with Fibromyalgia.


The role of vitamin D in the etiopathogenesis of fibromyalgia and non-specific musculoskeletal pain is controversial. In our study, we aimed to investigate the effect of vitamin D therapy on quality of life in patients with fibromyalgia.


Seventy patients diagnosed with fibromyalgia and 65 age- and sex-matched controls were included in the study. Patients were grouped as deficient (<20 ng/mL), inadequate (20-30 ng/mL), and sufficient (>30 ng/mL) according to the levels of vitamin D. Vitamin D replacement was performed for patients with deficiencies and inadequacies.

Before and after vitamin D therapy, patients filled in the assessment tools, fibromyalgia impact questionnaire (FIQ), Arizona sexual experience scale (ASEX), Beck depression inventory (BDI), visual analog scale (VAS), and short form-36 (SF-36).


Vitamin D deficiencies and inadequacies were observed in 60% of the patients (n=42). Among patients with low and normal levels of vitamin D, no statistically significant difference was observed in their values.

In scales examined after vitamin D replacement therapy, statistically significant differences were observed in the FIQ, BDI, VAS, and SF-36 compared with pre-treatment.


Vitamin D deficiency seems to be linked to the pathogenesis of fibromyalgia. Vitamin D supplementation may improve the quality of life in patients with fibromyalgia.

Full text available here.

Source:  Dogru A, Balkarli A, Cobankara V, Tunc SE, Sahin M. Effects of Vitamin D Therapy on Quality of Life in Patients with Fibromyalgia. Eurasian J Med. 2017 Jun;49(2):113-117. doi: 10.5152/eurasianjmed. 2017.16283.

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One thought on “Effects of Vitamin D Therapy on Quality of Life in Patients with Fibromyalgia.”

  1. IanH says:

    I think VitD deficiency is a risk factor but I know too many people with FM for whom this was clearly not the case. Despite that it may be a weak risk factor Vitamin D replenishment is still vital in FM and ME. Both FM and ME affect much physiology and to ensure minimal aging or damage vitamin D should be taken 5000IU daily. Many physicians think that FM and ME are not injurious illnesses but I have seen too many illnesses or pathologies exacerbated by FM and ME. Vitamin D will help to minimize this.

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