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Lyme disease is a tick-born infection first reported in United States of America in 1977 by Allen C. Steere. It occurred in the state of Connecticut; other cases have been discovered in others states of USA and also in other countries (Canada, Soviet Union, Japan, China, Australia). This
disease has not been reported in South America yet. In order to investigate this
disease in Brasil, a multi-disciplinary group including microbiologists, entomologists and clinicians was created at the University of São Paulo. The aim of this report is to describe the elaboration of this research in our center and also to present the preliminary results.