Fatigue secondary to chronic illness: postpolio syndrome [PPS], Chronic Fatigue Syndrome (CFS), & multiple sclerosis

Estimates of the percentage of patients with postpolio

syndrome, chronic fatigue syndrome, and multiple sclerosis who

experience fatigue range from approximately 75% to 100%. In

this study we describe the severity of fatigue and its impact

on subjects with these three diagnoses. The Fatigue Severity

Scale, the Human Activity Profile, and the Nottingham Health

Profile were used to measure fatigue, activity, and health

status respectively of each diagnostic group as well as a

control group. Using a Kruskal-Wallis one-way analysis of

variance followed by a Bonferroni-adjusted Mann Whitney U test

all diagnostic groups reported significantly higher levels (p

= .0000 to p = .002) of fatigue and lower perceived health

status than the control group. Subjects with chronic fatigue

and multiple sclerosis also had significantly reduced activity

levels (p = .002 to p = .01) compared with the control group.

Further attention should be directed toward understanding the

relationship between fatigue and ability to engage in

activities as well as strategies for remediation and/or

compensation of the fatigue.

Packer TL, Sauriol A, Brouwer B

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