FEATURE ARTICLES – June 25, 2003:
* Combining Hydrocortisone and Fludrocortisone: An Effective Treatment for Chronic Fatigue Syndrome?
* Research: Evaluation of Dexamethasone Suppression Test in Fibromyalgia Patients With or Without Depression
* CFS News: NIH Workshop Summary (Neuro-Immune Mechanisms and Chronic Fatigue Syndrome)
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Combining Hydrocortisone and Fludrocortisone: An Effective Treatment for Chronic Fatigue Syndrome?
Dr. Charles Shepherd writes, “The cause and significance of hypocortisolism in ME/CFS (i.e., decreased production of the hormone cortisol from the adrenal glands) remains a subject of debate. All of the evidence so far indicates that the cause is more likely be central (i.e., in the brain) rather than peripheral (i.e., at the level of the adrenal glands, where the hormone is produced). In other words, the adrenal glands don’t seem to be receiving enough in the way of stimulatory messages from higher centers in the brain and this results in a reduced output of cortisol.”
Research: Evaluation of Dexamethasone Suppression Test in Fibromyalgia Patients With or Without Depression
According to the authors of this recent study, “it is known that most patients with FM also have depressive symptoms and depressive patients suffering from pain are not uncommon. Some investigators have therefore suggested a possible connection between FM and depression. While in most healthy persons dexamethasone administration suppresses cortisol synthesis from the adrenal cortex, such suppression is not usually observed in patients with depression.”
CFS News: NIH Workshop Summary (Neuro-Immune Mechanisms and Chronic Fatigue Syndrome)
Rich Van Konynenburg, Ph.D., writes, “In my opinion, one of the most significant talks presented at the NIH workshop (Neuro-Immune Mechanisms and Chronic Fatigue Syndrome) was given by Suzanne Vernon from the Centers for Disease Control and Prevention (CDC). She gave a summary of the ongoing work on CFS at the CDC, and focused particularly on their gene expression work.”
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RESEARCH SPOTLIGHT: Polyphenols
A diet rich in a class of bioflavonoids, the polyphenols, may reduce the risk of chronic disease by reducing oxidative stress, according to researchers at the Sookmyung Women’s University who published a study in the June issue of the Journal of the American College of Nutrition (22, 3:217-23, 2003). Based on epidemiological evidence showing dietary polyphenols reduce the risk of chronic disease, researchers compared the effects of polyphenol-rich and -depleted diets in 19 healthy, non-smoking women.
The two dietary interventions — polyphenol-rich and -depleted — lasted six days each, separated by a three-day washout period. Blood and urine samples were collected at baseline, day three and day six, and researchers analyzed them for oxidative stress markers, including plasma antioxidant vitamins, erythrocyte superoxide dismutase (SOD) activity and lymphocyte DNA damage.
The researchers concluded that “diets rich in polyphenols may decrease the risk of chronic disease by reducing oxidative stress.” To read more about this research, click on the link below:
Support and Inspiration in the Coping Corner!
Dealing with the day-to-day struggles of living with a chronic illness can be trying. Coping Corner is the spot where you can find the online support you need to get through your day. Featuring personal stories, advice columnist Eunice Beck, RN, book reviews, and more.
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Pro Health is happy to offer CFS & FM Webmaster Tools & Link Exchange Programs at ImmuneSupport.com! We have designed these features to enable CFS & FM sites all over the world to get connected so we can work together to share important information and resources with our readers.
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