Lyme disease is the most common tick-borne
disease in North America. Our review of the literature found few reports of
Lyme disease presented in the orthopaedic literature. However,
Lyme disease presenting as a popliteal cyst, with or without rupture, is rarely reported. We present 4 cases of
Lyme disease that initially presented to our pediatric orthopaedic clinic for treatment of a popliteal cyst. The early diagnosis and treatment of
Lyme disease may help prevent the often-devastating long-term sequelae of
Lyme disease. The goal of this article is to increase the awareness of
Lyme disease presenting in children as a popliteal cyst.