Lymphocyte subsets, apoptosis, & cytokines in patients with Chronic Fatigue Syndrome (CFS)

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Whether immunologic abnormalities correlate with fatigue
severity and functional impairment in chronic fatigue syndrome
(CFS) was investigated. Blood mononuclear cells were
immunophenotyped and circulating ex vivo-produced cytokines
were measured in 76 CFS patients and 69 healthy matched
controls. Expression of CD11b on CD8 cells was significantly
decreased in CFS patients. However, the previously reported
increased expression of CD38 and HLA-DR was not confirmed.

There was no obvious difference in apoptosis in leukocyte
cultures, circulating cytokines, and ex vivo production of
interleukin (IL)-1 alpha and IL-1 receptor antagonist.

Endotoxin-stimulated ex vivo production of tumor necrosis
factor-alpha and IL-beta was significantly lower in CFS. The
immunologic test results did not correlate with fatigue
severity or psychologic well-being was measured by Checklist
Individual Strength, Beck Depression Inventory, and Sickness
Impact Profile. Thus, these immunologic tests cannot be used
as diagnostic tools in individual CFS patients.

Swanink CM, Vercoulen JH, Galama JM, Roos MT, Meyaard L, van der
Ven-Jongekrijg J, de Nijs R, Bleijenberg G, Fennis JF, Miedema F, van der
Meer JW

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