Met-enkephalin increase in patients with fibromyalgia (FM) under local treatment

Fibromyalgia is a chronic debilitating condition of unknown
etiology. The clinical picture suggests increased activity
and/or supersensitivity in nociceptive pathways or inadequate
activity in endogenous pain attenuation mechanisms. One
therapeutic approach in the treatment of this syndrome is the
administration of serial local injections of lidocaine
hydrochloride in the painful points. To evaluate the effect of
this treatment on plasma met-enkephalin (ME) levels we studied
15 patients, all women with fibromyalgia under local treatment
in the tender points, grouped as follows: 5 were treated with
local injection of lidocaine hydrochloride, 5 were treated
with local injection of saline and 5 treated with dry
needling. Significant increases in plasma ME concentrations
were observed in all groups in the last sampling of each
session studied. These results show an increase in plasma ME
levels 10 minutes after finishing each session, which is
independent of the maneuver employed.

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