Neurocognitive Consequences of Sleep Deprivation – Source: Seminars in Neurology, Sep 2009

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Sleep deprivation is associated with considerable social, financial, and health-related costs, in large measure because it produces impaired cognitive performance due to increasing sleep propensity and instability of waking neurobehavioral functions.

Cognitive functions particularly affected by sleep loss include psychomotor and cognitive speed, vigilant and executive attention, working memory, and higher cognitive abilities.

Chronic sleep-restriction experiments – which model the kind of sleep loss experienced by many individuals with sleep fragmentation and premature sleep curtailment due to disorders and lifestyle – demonstrate that cognitive deficits accumulate to severe levels over time without full awareness by the affected individual.

Functional neuroimaging has revealed that frequent and progressively longer cognitive lapses, which are a hallmark of sleep deprivation, involve distributed changes in brain regions including:

•  Frontal and parietal control areas,

•  Secondary sensory processing areas,

•  And thalamic areas.

There are robust differences among individuals in the degree of their cognitive vulnerability to sleep loss:

•  That may involve differences in prefrontal and parietal cortices,

•  And that may have a basis in genes regulating sleep homeostasis and circadian rhythms.

Thus, cognitive deficits believed to be a function of the severity of clinical sleep disturbance may be a product of genetic alleles associated with differential cognitive vulnerability to sleep loss.

Source: Seminars in Neurology, Sep 2009;29(4):320-39. PMID: 19742409, by Goel N, Rao H, Durmer JS, Dinges DF. Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. [E-mail:]

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2 thoughts on “Neurocognitive Consequences of Sleep Deprivation – Source: Seminars in Neurology, Sep 2009”

  1. panda22 says:

    Great article. I have been saying forever that when I don’t sleep it triggers pain/flare…I am not so sure extended sleep deprevation isn’t what kicked off my Lupus to begin with.

  2. Novotny says:

    Hello !

    I have two years of sleep deprivation as I think I have
    ‘candida’ infection.

    So far no doctor in Vancouver was able to help me as all
    they said ” I cant see anything wrong in your mouth , just
    gargel with salty water …..”

    I wake up at nite with burning tongue dry throat , day time
    ok but the skin is peeling of my lower inner mouth and
    I did have same large pimples with white tips….

    After two years I start to have chest pains ! Now the hart
    doctors are able to apply the hart procedures but I did not
    accept it till they help me to correct my underlying condition which causing me several waking per night .

    I was told that sleeples restles night= sleep depravation does not cause hart problems.

    I do not accepting this.

    Any input is very welcome.


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