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Phagosomal TLR signaling upon Borrelia burgdorferi infection.

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Abstract

Internalization and degradation of live Bb within phagosomal compartments of monocytes, macrophages and dendritic cells (DCs), allows for the release of lipoproteins, nucleic acids and other microbial products, triggering a broad and robust inflammatory response. Toll-like receptors (TLRs) are key players in the recognition of spirochetal ligands from whole viable organisms (i.e., vita-PAMPs). Herein we will review the role of endosomal TLRs in the response to the
Lyme disease spirochete.

Front Cell Infect Microbiol. 2014 May 20;4:55. doi: 10.3389/fcimb.2014.00055. eCollection 2014. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov’t; Review

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