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In an effort to bring more standardization to the chronic fatigue syndrome (CFS) Fukuda et al. case definition , the Centers for Disease Control and Prevention (CDC) has developed an empirical case definition  that specifies criteria and instruments to diagnose CFS.
The present study investigated the sensitivity and specificity of this CFS empirical case definition with diagnosed individuals with CFS from a community based study that were compared to non-CFS cases.
All participants completed questionnaires measuring:
• Disability (Medical Outcome Survey Short-Form-36) ,
• Fatigue (the Multidimensional Fatigue Inventory) ,
• And symptoms (CDC Symptom Inventory) .
Findings of the present study indicated sensitivity and specificity problems with the CDC empirical CFS case definition.
Source: Scientific Research – Psychology, Apr 2010. 1(1), pp 1-63. DOI:10.4236/psych.2010.11002, by Jason LA, Evans M, Brown A, Brown M, Porter N, Hunnell J, Anderson V, Lerch A. DePaul University, Chicago, Illinois, USA. [Email: Ljason@depaul.edu]