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Serological distinction between syphilis and Lyme borreliosis.

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The serological distinction of an immune response to the agent of syphilis, Treponema (T.) pallidum, and
Lyme disease borreliae is difficult due to the existence of cross-reacting antibodies. In this study, the immunoblot technique is used to compare the immune response of sera from patients with syphilis or
Lyme borreliosis to either T. pallidum or Borrelia (B.) burgdorferi. Patients with syphilis showed an IgG response to the 17 and 15 kDa antigens of T. pallidum, whereas sera from patients with
Lyme borreliosis-especially in late stages of the
disease-reacted with the 95 and 19-17 kDa antigens of B. burgdorferi. Thus, IgG antibodies against low molecular weight antigens of T. pallidum (17, 15 kDa) or B. burgdorferi (19-17 kDa) may represent useful markers for the serological diagnosis of syphilis or
Lyme borreliosis.

Zentralbl Bakteriol. 1994 Jan;280(3):319-24. Comparative Study

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