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Small Fiber Neuropathy Fibromyalgia Studies Mount: But Does SFN Cause Pain in FM?

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Reprinted with the kind permission of Cort Johnson and Health Rising.

Researchers have quickly jumped on the small nerve fiber neuropathy (SFN) finding in Fibromyalgia. After starting out with smaller studies some bigger ones are starting to show up, and the outlines of SFN prevalence in FM are beginning to emerge.

This Greek study was not particularly big – 46 FM patients – but it was a step in the right direction. It also included a significant subset (30%) of FM patients with autoimmune disorders in its cohort. They noted that SFN is the most common type of neuropathy in Sjogren’s Syndrome, a female-dominated autoimmune disorder (that may be under-diagnosed in ME/CFS and FM). As an added bonus they also examined Langerhorn cells and stained the skin biopsies for IL-6 in a small number of patients.

In the introduction the authors went straight to the immune system – cytokines and mast cells – as a possible cause for the increased rates of SFN found in Fibromyalgia.

Let’s see what they found.


The 35% of FM patients found to have significantly reduced nerve densities in their skin in this study was roughly in line with findings from other studies.

It’s not clear yet how how SFN contributes to the symptoms in FM. In some ways the two conditions don’t fit. SFN is a “length dependent process” that usually shows up as pain and/or other symptoms (tingling, numbness) at the ends of long nerves in the feet and hands. Pain and tingling in the feet can show up in Fibromyalgia, but FM is usually characterized by diffuse, not localized and deep, not surface, pain that is often worse in the upper body.

Indeed, the fact that pain intensity in this study was not correlated with reduced nerve fiber density suggests the SFN in FM may not be contributing to much of the pain seen in FM. On other hand, when pain is present in SFN it’s been associated with excessive firing of the remaining nerves – which has been found in FM. The upshot is that we just don’t know how small fiber neuropathy contributes to the pain in FM – we just know SFN is present.

It’s possible that the SFN in FM does extend to the upper body, but studies have not confirmed that. One researcher has suggested the nerve damage extends deeper into the body in FM, but we don’t know that either. There’s still much to learn about where and how often SFN is found in FM.

SFN Prevalence in Fibromyalgia Underestimated?

The authors suggested that the 30-40% of FM patients indicated as having SFN in the studies thus far is probably a low ball figure. The limited testing done so far – done at one or two points in the body – probably misses, they suggested, many FM patients with SFN in other parts of the body. No studies, for instance, have yet examined nerve fiber density at the well-defined “tender spots” in FM patients. SFN in other disorders is usually found at the ends of the longest nerves in the body but it’s not clear, as well, if it’s limited to the extremities in FM. Hopefully the next set of SFN studies will examine nerve density in the FM tender points and the upper body.

Not Getting at the Cause… Yet

Determining the cause of the SFN found, is of course, critical. The authors of this study proposed that an autoimmune process that attacked not the small nerve fibers in the skin but the small ganglionic neurons they’re connected to was a likely candidate. They pointed to the high rate of FM patients with autoimmune disorders (30%) in this study, and noted that some FM patients significantly improve on IVIG. [In another Health Rising blog Dr. Siveri noted that FM is a complex condition that requires multiple points of attack and that IVIG alone is not likely to be the answer.]

Neither these authors’ brief look at immune functioning (Langerhorn cells, IL-6 staining) in a small number of patients nor a recent study found evidence of immune alterations in the skin in FM. If it’s not the immune system then neuroinflammatory factors that cause neuronal degeneration could be at work.

Who wants to bet that something completely unexpected and possibly novel is at work? Disorders like FM and ME/CFS have not given up their secrets easily.

Psychological Slant Takes a Hit With Small Nerve Fiber Findings

These patients are often labeled as having a psychiatric disease, even though they do not fit into a true primary psychiatric disorder, nor do they have history of stressful or depressive events preceding the onset of their painful syndromes.”

The authors’ last words reflect a belief that recent findings are breaking up the default conversation that both FM and ME/CFS are psychiatric disorders. [Similar comments were recently made by Stanford researchers regarding their recent brain findings in ME/CFS.] They also bring to mind a psychiatrist’s recent study on the efficacy of antiviral therapy in adolescents with ME/CFS. Many of the adolescents had been diagnosed with treatment-resistant depression despite the fact they did not meet the criteria for depression (!).

I had a similar experience 25 years ago. I had a very smart doctor who surely knew the criteria for depression, but who sent me to a psychologist who quickly realized that I didn’t have any symptoms of depression. I’ll never forget the undertones of anger in that doctor’s voice as he sent me on my way. Never mind that I clearly wasn’t depressed; this doctor’s default response to cases like mine that confused him was to get angry and then send me to a psychologist. He probably did that dozens of times during his medical career.

This mindset has pervaded parts of the medical profession as long as poorly-defined disorders have been around. A medical establishment able to conclude or even speculate at one point that the crippling effects of multiple sclerosis reflected a mental derangement could easily conclude today that disorders like FM and ME/CFS are mental. Medical tests are more sophisticated now, but the human mind is not.


The authors noted the “notoriously negative laboratory workups” FM patients are known for. The accumulating evidence that SFN is present in FM suggests those negative laboratory workups may be a thing of the past for many. Skin biopsies for SFN are easy to do, are not particularly expensive and, with Therapath validating another testing spot on the body, are more comprehensive than before.

The findings are still, however, being ignored by some major figures in FM. In a recent WebMD article on “The Latest in FM Diagnosis and Care” Dr. Clauw – an advocate of the role central sensitization plays in FM – failed to mention the SFN findings.

Large-scale studies are needed now to determine how common SFN is in FM, why it’s present, and how it’s affecting the symptoms that patients experience. The continuing flow of SFN studies indicates that the research community is jumping on SFN findings this time.


About the Author: Cort Johnson has had ME/CFS for over 30 years. The founder of Phoenix Rising and Health Rising, Cort has contributed hundreds of blogs on chronic fatigue syndrome, fibromyalgia and their allied disorders over the past 10 years. Find more of Cort’s and other bloggers’ work at Health Rising.

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3 thoughts on “Small Fiber Neuropathy Fibromyalgia Studies Mount: But Does SFN Cause Pain in FM?”

  1. IanH says:

    I always appreciate Cort’s writings. He summarizes research and adds possibilities in a balanced way.

    It always amazes me how many studies, such as on SFN seem to treat FM or ME as some kind of pathological adjuct rather than accepting them as an immune system illness in their own right.

    I have no doubt that a form of SFN occurs in FM as it occurs in other illnesses such T2D. FM is not SFN, SFN is a result of the changes in the immune system affecting nerve fibre function. Some FM people have low nerve density but others do not. The question is:
    Does this difference reflect in symptoms, for example do people with FM + low density peripheral innervation have pain reflective of this and do those people with FM with normal innervation have an absence of these symptoms?

    If so we can then test whether the differences in symptoms are due to differences in genetics. The illness than may be the same illness just expressed differently. After all, at the level of the immune system any changes may result in symptom differences due to differences in gene expression.

  2. telmaquintan says:

    I am feeling all of them, what you describe here.
    Also, in the tender points, some days are worst than the others day, but also I am feeling this in my face, part of the maxilar, ear, neck, of. Course in my fingers, toes, wrist, thigh, buttocks, I could not hold heavy things, because my hands does not help me, my thumb hurstme a lot.

  3. clareHB says:

    My fibro friends and I have discussed this and some new criteria for diagnosing FM. I don’t think that this change (“evidence based”) in some doctor’s approaches to fibromyalgia is any better solution though used in conjuction with TPs may be helpful. Your article and others on the research associating it with small fiber polyneuropathy in many cases is enlightening. I thank you for this informative writing. It is concise and I like that it comes from someone who has had his eye on the ball for years.

    If more doctors, general practitioners especially, would heed this research, they might get a better understanding. I find too many who dismiss FM as though we are exaggerating our pain and anxiety, or worse, that it is a figment of our imagination. Psychosomatic huh. Perhaps minds will open up to research and articles like yours that continue to educate the community. Once again, thank you.

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