Soy and Isoflavone Consumption Reduces Prostate Cancer Risk in China

"This case-control study in China evaluated the effect of soy food consumption and isoflavones (genistein and daidzein) on the risk of prostate cancer," scientists in the United States report.

"One hundred and thirty-three cases and 265 age- and residential community-matched controls between the ages of 50 and 89 years were interviewed in person between 1989 and 1992. Usual consumption of soy foods and isoflavones was assessed using a food frequency questionnaire developed in China and a nutrient database developed and validated in Asian-American populations," wrote M.M. Lee and colleagues, University of California San Francisco, Department of Epidemiology & Biostatistics.

"The age- and total calorie-adjusted odds ratio (OR) of prostate cancer risk comparing the highest tertile of tofu intake to the lowest tertile was 0.58 [95% confidence interval (CI), 0.35-0.96]," the researchers wrote.

"There were also statistically significant associations comparing the highest quartile of intake of soy foods (OR, 0.51; 95% CI, 0.28-0.95) and genistein (OR, 0.53; 95% CI, 0.29-0.97) with the lowest quartiles," the researchers stated.

"There was also an indication of a reduced risk associated with intake of daidzein (OR, 0.56; 95% CI, 0.31-1.04 for the highest versus lowest quartile). Our results indicate a reduced risk of prostate cancer associated with consumption of soy foods and isoflavones," they added.

The researchers concluded: "These findings should be confirmed in longitudinal follow-up studies in populations with varying risk of prostate cancer."

Lee and colleagues published their study in Cancer Epidemiology Biomarkers & Prevention (Soy and isoflavone consumption in relation to prostate cancer risk in China. Cancer Epidem Biomarkers Prev, 2003;12(7):665-668).

For additional information, contact M.M. Lee, University of California San Francisco, Department of Epidemiology & Biostatistics, MU 420 W, Box 0560, San Francisco, CA 94143, USA.

The publisher's contact information for the journal Cancer Epidemiology Biomarkers & Prevention is: The American Association for Cancer Research, PO Box 11806, Birmingham, AL 35202, USA.

The information in this article comes under the major subject area of Oncology. This article was prepared by Biotech Week editors from staff and other reports.

© Copyright 2003, Biotech Week via

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