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Supplementation with vitamins C and E associated with decreased risk of cognitive impairment, dementia

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Reprinted with the kind permission of Life Extension.

November 2 2016.An article that appeared on October 4, 2016 in the Annals of Pharmacotherapy reports an association between the intake of vitamin C and E supplements and a lower risk of developing cognitive decline among men and women aged 65 years and older.

The current investigation included 5,269 men and women who were free of dementia upon enrollment in the Canadian Study of Health and Aging from 1991 to 1992. Follow-up examinations conducted during 1996-1997 and 2001-2002 provided post-enrollment diagnoses of dementia or cognitive impairment without dementia. Information concerning current use of prescription drugs and vitamins was ascertained from interview or questionnaire responses at the beginning of the study.

Approximately 10% of the subjects reported using vitamin C or E. Over up to 11 years of follow up, 821 cases of all-cause dementia (including 560 Alzheimer’s disease cases) were diagnosed and 882 cases of cognitive impairment without dementia developed. In comparison with those who did not report supplementing with either vitamin, the use of vitamin C and/or vitamin E was associated with a 38% lower adjusted risk of all-cause dementia and a 40% lower risk of Alzheimer’s disease. For cognitive impairment without dementia, the risk was 23% lower among those who used either or both vitamins. Evaluation of the effects of using either vitamin alone resulted in associations with similar risk reductions.

 “This study supports a protective role of vitamin E and C supplements in the risk for Alzheimer’s disease and all-cause dementia,” authors Luta L. Basambombo, MSc, of CHU de Québec Research Center and colleagues conclude. “In addition, these supplements may contribute to a reduced risk of CIND [cognitive impairment, not dementia]. Overall, these findings indicate additional support for the use of antioxidants as a preventive strategy against cognitive decline.”

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