Systematic review: faecal microbiota transplantation therapy for digestive and nondigestive disorders in adults and children

1 Star2 Stars3 Stars4 Stars5 Stars (3 votes, average: 4.00 out of 5)
Loading...

By S. Sha et al.

Abstract

BACKGROUND: There has been growing interest in the use of faecal microbiota transplantation (FMT) for the treatment of gastrointestinal and nongastrointestinal diseases.

AIM: To review systematically the reported efficacy and safety of FMT in the management of gastrointestinal and nongastrointestinal disorders in adults and children.

METHODS: The systematic review followed Cochrane and PRISMA recommendations. Available articles were identified using three electronic databases in addition to hand searching and contacting experts. Inclusion criteria were any reports of FMT therapy written in English.

RESULTS: A total of 844 patients who had undergone FMT were identified from 67 published studies. The most common indications were refractory/relapsing Clostridium difficile infection (CDI) (76.3%) and inflammatory bowel disease (IBD) (13.2%). There has been only one placebo-controlled trial, a successful trial in 43 patients with recurrent CDI.

Seven publications report FMT in paediatric patients with a total of 11 treated, 3 with chronic constipation and the remainder with recurrent CDI or ulcerative colitis (UC). 90.7% of patients with refractory/relapsing CDI were cured and 78.4% of patients with IBD were in remission after FMT. FMT therapy could also be effective in treatment of some nongastrointestinal disorders such as chronic fatigue syndrome. The only reported serious adverse event attributed to the therapy was a case of suspected peritonitis.

CONCLUSIONS: Although more controlled trials are needed, faecal microbiota transplantation therapy shows promise in both adults and children with gastrointestinal diseases such as CDI and IBD.

Source: Sha S, Liang J, Chen M, Xu B, Liang C, Wei N, Wu K. Aliment Pharmacol Ther. 2014 Mar 18. doi: 10.1111/apt.12699. [Epub ahead of print]
© 2014 John Wiley & Sons Ltd.

Related articles

Breath test for differential diagnosis between small intestinal bacterial overgrowth and irritable bowel disease: An observation on non-absorbable antibiotics – Source: World Journal of Gastroenterology, Dec 7, 2007
Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: Effects of age, duration of illness and the translocation of LPS from gram-negative bacteria – Source: Neuro Endocrinology Letters, Dec 29, 2008
Abstract: Serotonin Mechanisms in Pain and Functional Syndromes — Management Implications in Comorbid Fibromyalgia, Headache, and Irritable Bowel Syndrome: Case Study and Discussion
How does cognitive behavior therapy for Irritable Bowel Syndrome work? A mediational analysis of a randomized clinical trial
Clinical trial: Short- and long-term benefit of relaxation training for Irritable Bowel Syndrome – Source: Alimentary Pharmacology & Therapeutics, Sep 2007
1 Star2 Stars3 Stars4 Stars5 Stars (3 votes, average: 4.00 out of 5)
Loading...



Leave a Reply