The analgesic effects of selective serotonin reuptake inhibitors

Source: J Psychopharmacol 1998;12(4):407-13

This paper endeavours to provide a critical clinical review of

the use of selective serotonin reuptake inhibitors (SSRIs) in

the management of pain. Case reports, placebo-controlled

trials and trials comparing SSRIs with tricyclic

antidepressants (TCAs) are considered. The analgesic effects

of TCAs are well known and this review suggests that there is

little evidence for their replacement by SSRIs in pain

management. There are, at present, too few comparative drug

trials to make a definitive statement, although the trend is

clearly against SSRIs.

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