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The emergence of Lyme disease.

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Abstract

Since its identification nearly 30 years ago,
Lyme disease has continued to spread, and there have been increasing numbers of cases in the northeastern and north central US. The
Lyme disease agent, Borrelia burgdorferi, causes infection by migration through tissues, adhesion to host cells, and evasion of immune clearance. Both innate and adaptive immune responses, especially macrophage- and antibody-mediated killing, are required for optimal control of the infection and spirochetal eradication. Ecological conditions favorable to the
disease, and the challenge of prevention, predict that
Lyme disease will be a continuing public health concern.

J Clin Invest. 2004 Apr;113(8):1093-101. Research Support, Non-U.S. Gov’t; Research Support, U.S. Gov’t, P.H.S.; Review

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