Vitamin B status in patients with Chronic Fatigue Syndrome (CFS)

Some patients with chronic fatigue syndrome say they benefit

from taking vitamin supplements. We assessed functional status

for the B vitamins pyridoxine, riboflavin and thiamine in 12

vitamin-untreated CFS patients and in 18 healthy controls

matched for age and sex. Vitamin-dependent

activities–aspartate aminotransferase (AST) for pyridoxine,

glutathione reductase (GTR) for riboflavin, transketolase (TK)

for thiamine–were measured in erythrocyte haemolysates before

and after in-vitro addition of the relevant vitamin. For all

three enzymes basal activity (U/g Hb) was lower in CFS

patients than in controls: AST 2.84 (SD 0.62) vs 4.61 (1.43),

P < 0.001; GTR 6.13 (1.89) vs 7.42 (1.25), P < 0.04; TK 0.50
(0.13) vs 0.60 (0.07), P < 0.04. This was also true of
activated values: AST 4.91 (0.54) vs 7.89 (2.11), P < 0.001;
GTR 8.29 (1.60) vs 10.0 (1.80), P < 0.001; TK 0.56 (0.19) vs
0.66 (0.08), P < 0.07. The activation ratios, however, did not
differ between the groups. These data provide preliminary

evidence of reduced functional B vitamin status, particularly

of pyridoxine, in CFS patients.

Heap LC, Peters TJ, Wessely S

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