Superagers have the longevity genes to help them age superbly, but it's their epigenetic changes made by specific lifestyle choices that account for an estimated 80% of the battle. 

Phosphatidylserine and ashwagandha are two promising supplements for supporting cognitive health at any age.

World Trade Center responders with current PTSD present with premature aging, altered gene activity called transcriptional aging, and accelerated epigenetic biological clocks.

Mice subjected to chronic stress exhibit depressive symptoms and cognitive loss that correlate with senescence—permanent cell cycle arrest from damage or stress that is characteristic of aging.