Graying hair is caused by a combination of age, genetics, oxidative damage, emotional stress levels, smoking, and certain nutrient deficiencies. Recent research using human hair samples has found that graying hair is a reversible process. 

DNA damage accelerates aging and chronic disease development. In mice, supplemental NMN boosted NAD+ levels, allowing for the DNA repair protein PARP1 to be fully functioning and reduce this damage, which may improve health and increase lifespan.

A buildup of senescent cells (dysfunctional cells that have stopped dividing) is linked to disease development and aging. Slow down senescence through senolytic drugs or supplements, NMN supplementation, and caloric restriction. 

Berberine supports health by maintaining blood sugar and lipid levels, and supporting metabolism, liver, and brain health. Combining berberine with NMN and trans-resveratrol may further support these benefits.